This Thursday, 28.04 at 11:00 am we will have a FH seminar where Dr. Barak Raveh from Hebrew University of Jerusalem will give a lecture titled "Integrative modeling of dynamic molecular and cellular systems across scales". See the details in the file attached.
Please note that the lecture will be held at the Los Angeles lecture hall. 
Living cells, tissues, and entire organisms are dynamic systems of moving parts. The interactions
between these parts give rise to the collective behavior of these systems, which ultimately yields
Life. Experimental or theoretical methods for characterizing biological systems are typically
restricted to only subsets of relevant spatial and temporal scales, limiting their utility for
characterizing these systems holistically. Integrative multiscale modeling is a general approach for
bridging this gap by systematically combining data from different methods at different scales. Using
this approach, we modeled the nucleocytoplasmic transport system, which regulates the molecular
traffic in and out of the cell’s nucleus. This system comprises many millions of atoms that interact
over a wide range of timescales and plays a key role in both health and disease. We modeled the
entire transport system based on data from a large number of experimental and theoretical sources,
specified at multiple scales and varying degrees of data uncertainties. The resulting spatiotemporal
model recapitulates independent experimental measurements of transport rates and elucidates
fundamental properties of the transport system, including the mechanism by which it filters by size
and how it functions both rapidly and selectively at the same time. As we now strive to expand the
scope and depth of our modeling, I will also discuss our ongoing efforts to develop new and more
scalable methods for integrative modeling of dynamic biological systems across representations and
scales.